Associate Professor, University of North Dakota
Dr. Brissette’s research focuses on bacteria-host interactions, with a particular interest in pathogenic spirochetes. The overarching theme of her laboratory is to discover how these microbes persist and cause long-term infections. Dr. Brissette is particularly interested in understanding why B. burgdorferi has tropism for the central nervous system, and in elucidating the function of outer surface proteins that interact with the mammalian host. Current GLA-funded research project: “Epigenetic modifications induced by Borrelia burgdorferi: implications for persistent symptoms”
“Epigenetic modifications induced by Borrelia burgdorferi: implications for persistent symptoms”
Neurological symptoms may persist in a significant number of Lyme patients. Dr. Brissette studies whether the regulation of gene expression may differ in brain cells exposed to Borrelia compared to unexposed cells. This will pave the way to new understanding of neurological manifestations of Lyme disease.