Professor of Pathology, Microbiology & Immunology, Center for Comparative Medicine, School of Veterinary Medicine, University of California, Davis, CA
Antibodies, made by the immune system, are important in controlling infections. The carbohydrates attached to them may affect how well they function. Dr. Baumgarth will study how B. burgdorferi infection in mice promotes changes in the composition of these sugars, which may be another tactic used by the bacteria to cause immune dysfunction.
STUDY (2017-18): “Defining protective antibody-mediated immunity to Borrelia burgdorferi”
An abnormal immune response to B. burgdorferi may be one reason why we become sick from Lyme disease and in some cases, continue to be ill after antibiotic treatment. Using the mouse model of Lyme disease, Dr. Baumgarth studies the role of helper CD4+ T cells, which may fail to respond appropriately, and cause antibodies to remain high on Western Blots.
STUDY (2016-17): “Immune cell dysfunction in mouse model of Lyme disease”