GLA’s grant application process consists of two stages:
I. Letter of Intent (LOI): Applicants submit a 1-page overview of their proposed project. Only a simple budget and biosketch are required at this stage. LOIs will be reviewed for feasibility and programmatic alignment before invitation to the full proposal stage. The Letter of Intent deadline is June 30, 2025, 11:59pm ET.
II. Full Proposal (by invitation only): Invited applicants will submit more detailed information, including a 6-page proposal, detailed budget, and supporting materials. Full proposals will be reviewed by GLA’s Scientific Advisory Board, following a process modeled after the National Institutes of Health, to identify and support projects of the highest scientific merit and potential for impact. The Full Proposal tentative deadline is September 15, 2025, 11:59pm ET.
*Timeline is subject to change depending on application volume or other circumstances.
Global Lyme Alliance (GLA) is the leading 501(c)(3) dedicated to combatting Lyme and other tick-borne diseases through innovative research, awareness, and empowering the patient voice. GLA has awarded over $20 million in research funding through more than 70 grants to study Lyme and other tick-borne diseases. GLA supports high-quality, evidence-based, and data-driven research that advances scientific knowledge and contributes to improving patient outcomes.
GLA prioritizes research that accelerates the development of innovative diagnostics, elucidates disease mechanisms, and advances novel treatment strategies for Lyme and other tick-borne diseases. A particular emphasis is placed on understanding and addressing post-treatment and chronic manifestations of Lyme disease.
1. Diagnostics
GLA supports research aimed at developing accurate diagnostic tools for Lyme and other tick-borne diseases. Priority areas include:
GLA seeks to advance understanding of the biological processes that drive infection, immune dysfunction, and neuroinflammation in Lyme disease and PTLDS. Areas of interest include:
GLA prioritizes research into innovative therapeutic approaches aimed at improving patient outcomes, with a focus on:
GLA supports epidemiologic research to improve the understanding of Lyme and tick-borne disease prevalence, risk factors, and disease burden across diverse populations. Key areas include:
GLA encourages interdisciplinary collaborations and the use of cutting-edge technologies, such as multi-omics, artificial intelligence-driven diagnostics, and advanced in vivo models, to drive transformative discoveries in Lyme disease research.
GLA welcomes research proposals from qualified applications worldwide. The principal investigator (PI) on applications should typically hold a PhD, MD, or other advanced degree relevant to the research proposal. Graduate students are not eligible to serve as PI on these awards.
The maximum budget is $175,000 per year, including indirect costs of up to 10%, with a maximum project duration of two years unless otherwise discussed.
LOIs must be one page, single-spaced, using Arial 11-point font with 0.5-inch margins. The following sections must be included:
All LOIs must adhere to these guidelines for consideration.
Letter of Intent Deadline June 30, 2025, 11:59pm ET
GLA conducts a programmatic review of LOIs to identify those with the strongest alignment to the 2025 Research Focus Areas and the greatest potential for feasibility and impact. Applicants invited to submit full proposals must be submitted online via the following portal. Word, PDF, or Excel files are accepted for each section.
Include biographical sketches of the PI and all key personnel referenced in the budget. A biosketch modeled on the NIH format is preferred and highly encouraged.
List all active and pending support (government, private, institutional, etc.) for the PI and key personnel, whether related to this proposal or not.
The total length must not exceed 6 pages (excluding abstracts, references, and appendices). Project descriptions exceeding 6 pages will not be reviewed. Please organize your project description in the following sequence. Suggested page limits are flexible, but the total must not exceed 6 pages:
Required Format: Applications must be in English, with single-spaced text using Arial 11 or larger point font, and 0.5-inch margins.
List of references, uploaded in its own field during application submission.
Provide a detailed budget and justification, including staff needs and itemized supplies. Applicants may request up to $175,000 USD per year, which must include both direct and indirect costs. GLA allows up to 10% institutional indirect costs as part of the total budget. Example: A $175,000 total request would include $157,500 in direct costs and $17,500 in indirect costs. For proposals over one year, include a budget for each year. If there are sub-awards, their budgets must also be outlined.
Permissible direct costs include:
Impermissible costs:
All awarded funds must be used solely for the purposes described in the approved application and budget. Note that budgets are sometimes reduced below the amount requested based on availability of funds and the scientific and programmatic merit of proposals.
If applicable, include a letter from collaborators at non-home institutions confirming their commitment to the study. The applicant is also encouraged to share pdf versions of any prior publications whose findings are directly relevant to the submitted research proposal. Materials may be combined into one PDF file to facilitate uploading.
For projects that involve laboratory animals, the Institutional Animal Care and Use Committee (IACUC) approval date and animal welfare assurance number must be provided. For non-US applicants, an equivalent document or letter from their host institute’s Animal Ethics Committee may be submitted.
For grant applications involving human subjects the following must be included:
An institutional statement and assurances regarding potential biohazards and safeguards must be included. In most cases, the institutional department of environmental health and safety (or equivalent office) can provide the applicant with a letter stating that the laboratory and/or the applicant is compliant with applicable laws. An equivalent document from applicants from non-US countries may be provided.
If applicable, briefly describe methods to ensure the identity and validity of key biological and/or chemical resources (maximum one page). These include reagents or samples that may vary between labs or over time and are crucial to the research, such as cell lines, antibodies, and patient samples. Standard lab reagents like buffers or growth media need not be included.
A signature page must be completed before submission. Signatures from the PI and an authorized institutional representative are required.
Applications will be reviewed by members of GLA’s Scientific Advisory Board (SAB) using the following criteria:
SAB members will score these sections using the NIH 1–9 scale, with 1 being the highest score (exceptional) and 9 the lowest (poor). This standardized scoring system allows reviewers to assess the overall impact and quality of each proposal.
Animals. The committee will evaluate the proposed use of live animals based on the procedures described, justification for choosing animals over alternative models, measures to minimize discomfort and pain, and the euthanasia method if not in line with AVMA Guidelines.
Budget. The committee will review the proposed budget for clarity and alignment with project goals. This includes evaluating staff compensation, supplies, and any sub-award budgets. The budget should reflect the appropriate use of requested funds to achieve project outcomes.
Biohazards and Authentication of Key Resources. Reviewers will assess any potential hazards posed by materials or procedures to research personnel and the environment, as well as the proposed protective measures. Additionally, for projects involving key biological or chemical resources, the review will include the adequacy of plans to authenticate and ensure the validity of these resources.
Cara DeAngelis, Ph.D., Director of Research
cara.deangelis@gla.org
Armin Alaedini, Ph.D., Chief Scientific Officer
armin.alaedini@gla.org
2023 © Copyright Global Lyme Alliance. All rights reserved.
Disclaimer: The above material is provided for information purposes only. The material (a) is not nor should be considered, or used as a substitute for, medical advice, diagnosis, or treatment, nor (b) does it necessarily represent endorsement by or an official position of Global Lyme Alliance, Inc. or any of its directors, officers, advisors or volunteers. Advice on the testing, treatment or care of an individual patient should be obtained through consultation with a physician who has examined that patient or is familiar with that patient’s medical history. Global Lyme Alliance, Inc. makes no warranties of any kind regarding this Website, including as to the accuracy, completeness, currency or reliability of any information contained herein, and all such warranties are expressly disclaimed.