Program Overview
Global Lyme Alliance (GLA) supports research that deepens understanding, improves diagnosis, and accelerates treatment of Lyme and other tick-borne diseases. Our research program supports projects across the full scientific spectrum, from foundational discovery to translational studies, while investing in critical infrastructure, including well-characterized biological sample collections. Together, these efforts speed breakthroughs that can improve patient care.
Why This Research Matters
Lyme and other tick-borne diseases are complex, often misunderstood, and present significant challenges for patients and clinicians alike. While most patients recover with prompt treatment, studies suggest that 10–20% continue to experience persistent symptoms such as fatigue, joint pain, or cognitive difficulties, for reasons that are not yet fully understood.
Strategic Focus Areas
To address these critical gaps, GLA’s Research Program funds high-quality projects that:
- Advance scientific understanding of disease mechanisms that drive infection, immune dysfunction, and neuroinflammation in Lyme disease
- Support innovative diagnostic tools that directly detect infection, identify patients with persistent symptoms, and help assess treatment effectiveness.
- Explore novel treatment approaches for patients with ongoing symptoms and interventions that may prevent long-term complications.
- Conduct epidemiologic studies to better understand prevalence, risk factors, and disease burden across diverse populations.
- Strengthen research infrastructure, including longitudinal patient sample collections, to accelerate discoveries and support the broader scientific community.
Scientific Oversight and Accountability
GLA’s research grants are rigorously evaluated by its Scientific Advisory Board (SAB), comprised of leading researchers and clinicians specializing in Lyme and tick-borne diseases, ensuring that the most promising projects with the greatest potential impact receive funding. Once funded, projects are closely monitored through regular check-ins and structured progress reports to ensure accountability, momentum, and meaningful outcomes.
