2019 Archives - Global Lyme Alliance 2019 Archives - Global Lyme Alliance

Two-Tier Lyme Disease Serology Test Results Can...

Variability in 2-tier Lyme disease test results according to the specific first-tier enzyme immunoassay (EIA) in children has not been examined rigorously. In this study, investigators paired results of clinical 2-tier Lyme disease tests to …MORE

The RpoS Gatekeeper in Borrelia burgdorferi: An...

This team, based at University of Connecticut, studied genes controlled by the RpoS pathway, the regulatory system that facilitates transmission and mammalian infection by Borrelia burgdorferi. They were particularly interested in whether RpoS-controlled genes are …MORE

The Lyme Disease Polymerase Chain Reaction Test...

The Lyme PCR is a direct detection test, but has not been rigorously evaluated in children undergoing evaluation for acute Lyme disease. Published in Vector-Borne and Zoonotic Diseases: https://www.liebertpub.com/doi/10.1089/vbz.2019.2547 PubMed: https://www.ncbi.nlm.nih.gov/pubmed/31821110

The Long-Term Persistence of Borrelia burgdorfe...

Whether Borrelia burgdorferi, the causative agent of Lyme disease, can persist for long periods in the human body has been a controversial question. The objective of this study was to see if we could find B. burgdorferi in a …MORE

The General Symptom Questionnaire-30 (GSQ-30): ...

The multi-system symptoms accompanying acute and post-treatment Lyme disease syndrome pose a challenge for time-limited assessment. The General Symptom Questionnaire (GSQ-30) was developed to fill the need for a brief patient-reported measure of multi-system symptom …MORE

The Functional and Molecular Effects of Doxycyc...

Recent studies have shown that Borrelia burgdorferi can form antibiotic-tolerant persisters in the presence of microbiostatic drugs such as doxycycline. Precisely how this occurs is yet unknown. The goal of this study was to examine gene …MORE

Stationary Phase Persister/Biofilm Microcolony ...

Although most patients with Lyme disease can be cured with a 2-4 week antibiotic therapy, about 10-20% of patients continue to suffer prolonged persistent symptoms, a condition called post-treatment Lyme disease syndrome (PTLDS). The cause …MORE

Lymphatic Migration of Immune Cells

Lymphatic vessels collect interstitial fluid that has extravasated from blood vessels and return it to the circulatory system. Another important function of the lymphatic network is to facilitate immune cell migration and antigen transport from …MORE

Identification of Essential Oils with Strong Ac...

Persister forms of Borrelia burgdorferi, the bacterium that causes Lyme disease, are dormant or slow-growing, and tolerant of antibiotic treatment. It’s not clear yet whether persister bacteria, immune dysfunction, or some combination of the two …MORE

Genomes, expression profiles, and diversity of ...

Dr. Alan Barbour and his team have analyzed the mitochondrial DNA from wild white-footed mice, Peromyscus leucopus. These mice are the natural host for Lyme and other tickborne bacteria, and serve as a reservoir from …MORE

Evaluation of the Modified Two-Tiered Testing M...

Conventional two-tiered testing (CTTT) for Lyme disease includes a first-tier enzyme immunoassay (EIA) followed by a supplemental immunoblot, and modified two-tiered testing (MTTT) relies on two different sequential EIAs without the inclusion of an immunoblot. …MORE

Estimation of cumulative number of post-treatme...

Joint study conducted by scientists at Global Lyme Alliance (GLA) and Brown University estimates that two million people in the United States could suffer profound disability from post-treatment Lyme disease syndrome (PTLD) by the year …MORE

DksA Controls the Response of the Lyme Disease ...

The pathogenic spirochete Borrelia burgdorferi senses and responds to changes in the environment, including changes in nutrient availability, throughout its enzootic cycle in Ixodes ticks and vertebrate hosts. This study examined the role of DnaK suppressor protein (DksA) in …MORE

Borrelia burgdorferi bbk13 Is Critical for Spir...

Borrelia burgdorferi (Bb) enters the human body via the bite of an infected Ixodes tick. Lyme disease symptoms arise from the dissemination of Bb from the initial bite site to the distal tissues such as the heart, the joints, …MORE

A minority of children diagnosed with Lyme dise...

Of 1770 children undergoing emergency department evaluation for Lyme disease, 362 (20.5%) children had Lyme disease. Of those with an available tick bite history, only a minority of those with Lyme disease had a recognized …MORE

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