2016 Archives - Global Lyme Alliance 2016 Archives - Global Lyme Alliance

Longitudinal Transcriptome Analysis Reveals a S...

The genes that are expressed in sick people differ from those who are healthy. Using advanced sequencing techniques, these researchers found that immune cells in the blood of people with Lyme disease express different genes …MORE

Expression of C-reactive protein and serum amyl...

The human immune response to invasive microbes consists of two major arms: the innate and the adaptive response. The innate response occurs rapidly after infection, when the host tries to contain or inactivate the microbe. …MORE

Eradication of Biofilm-Like Microcolony Structu...

The persistence of symptoms in Lyme patients treated with antibiotics may be due to the bacteria becoming tolerant to drugs. In lab culture, persistent Lyme bacteria grown into biofilm form were exposed to various antibiotic …MORE

Epitope-Specific Evolution of Human B Cell Resp...

Lyme disease patients make antibodies that recognize Borrelia burgdorferi, the bacteria that cause illness. When the disease progresses from early to late stages, these antibodies may change. A protein on the outside of B. burgdorferi …MORE

Ceftriaxone pulse dosing fails to eradicate bio...

At least 10% of patients treated with antibiotic therapy for Lyme disease continue to suffer persisting symptoms. The reason for this is unknown, but one suspect is the continued survival of persisting forms of B. …MORE

CCL19 as a Chemokine Risk Factor for Post Treat...

An estimated 10-20% of Lyme disease patients who are treated with antibiotics continue to suffer persisting symptoms 6 to 12 months later. This is known as post-treatment Lyme disease syndrome, because it may affect various …MORE

A drug combination screen identifies drugs acti...

In lab culture, Borrelia burgdorferi, the bacterium that causes Lyme disease, can survive amoxicillin treatment by transforming into a round-body form. Such round bodies persist in a slowly-growing state and are tolerant of antibiotics. In …MORE

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